منابع مشابه
Darkness descends with two Rabs
Over 60 distinct Rab GTPases regulate specific vesicular transport steps in the mammalian central vacuolar system. Wasmeier et al. (this issue, p. 271) reveal a redundant role for two tissue-specific Rab proteins in regulating transport to a tissue-specific lysosome-related organelle, the melanosome.
متن کاملVesicle transport : More work for the Rabs?
The Rab family of small GTP-binding proteins has long been implicated in the docking and fusion of transport vesicles with their target membranes. Recent evidence, however, suggests that some Rabs may play an additional role in transport vesicle formation.
متن کاملSpecific localization of Rabs at intracellular membranes.
Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely in the hypervariable C-terminus is incorrect, and a second mechanism involving a GDF [GDI (guanine-nucleotide-dissociation inhibitor) displacement factor] ...
متن کاملEndocytic Rabs in membrane trafficking and signaling.
The endolysosomal system controls the trafficking of proteins between the plasma membrane and the degradative environment of the lysosome. The early endosomal Rab5 and the late endosomal Rab7 GTPases have a key role in the transport along the endocytic pathway by recruiting tethering factors such as the hexameric CORVET and HOPS complexes that promote membrane fusion. Both Rabs are also involve...
متن کاملInto Darkness
Visual navigation of mobile robots has become a core capability that enables many interesting applications from planetary exploration to self-driving cars. While systems built on passive cameras have been shown to be robust in well-lit scenes, they cannot handle the range of conditions associated with a full diurnal cycle. Lidar, which is fairly invariant to ambient lighting conditions, offers ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200608058